l-Nucleosides as chemotherapeutic agents

Enzymes as Chemotherapeutic Agents

Fullerenes as Agents for Chemotherapeutic Drug Delivery

In a world where the scale of technology is continuously shrinking, from phones to cars to solar panels, nanotechnology is seeing a rise in applications. Recently, increased use of nanotechnology in the medical industry brought fullerenes, sometimes referred to as Buckyballs, to the forefront. Fullerenes are currently being developed by engineers to encapsulate a chemotherapeutic drug and deliv...

Quinolines as chemotherapeutic agents for leishmaniasis.

The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species(e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progre...

Metal Complexes as Drugs and Chemotherapeutic Agents

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Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents.

A series of unnatural L-nucleosides such as 3TC, FTC and L-FMAU have been found to be potent antiviral agents. The mode of action of L-nucleosides has been found to be similar to that of D-nucleosides as antiviral agents, despite their unnatural stereochemistry, that is, nucleotide formation by kinases followed by interaction with the reverse transcriptase (RT) of HIV or DNA polymerase. To date...